The UAN-NTA nanoparticle platform (NP) has been engineered for targeted delivery to organs involved in acute and chronic inflammation. Examining conformation -specific activity of integrins in YS2H and human cell lines will provide a method to probe endothelial interactions during lymphocyte migration in order to detect a trigger for inflammation.

The UAN-NTA NP with Mab will demonstrate cell specific delivery of diagnostic and therapeutic agents including dye (FITC/DPA), super paramagnetic iron oxide (SPIO), and camptothecin (CPT), to suppress an inflammatory response. The activation of endothelial-leukocyte adhesion can be controlled through the interactions of LFA-1 and Mac-1 with ICAM-1 to alter the role of lymphocyte function and macrophage efflux to the lymphatics.