publications:index

Publications

Since 2013 (Weill Cornell Medicine)

  1. Zhou B, Yuan Y, Shi L, Hu S, Wang D, Yang Y, Pan Y, Kong D, Shikov AN, Duez P, Jin M, Li X, Hu X. Creation of an Anti-Inflammatory, Leptin-Dependent Anti-Obesity Celastrol Mimic with Better Druggability. Front Pharmacol. 2021;12:705252. doi: 10.3389/fphar.2021.705252. eCollection 2021. PubMed PMID: 34526895creation2021.pdf
  2. Yang Y, McCloskey JE, Yang H, Puc J, Alcaina Y, Vedvyas Y, Gomez Gallegos AA, Ortiz-Sánchez E, de Stanchina E, Min IM, von Hofe E, Jin MM. Bispecific CAR T Cells against EpCAM and Inducible ICAM-1 Overcome Antigen Heterogeneity and Generate Superior Antitumor Responses. Cancer Immunol Res. 2021 Aug 2;. doi: 10.1158/2326-6066.CIR-21-0062. [Epub ahead of print] PubMed PMID: 34341066.bispecific2021.pdf
  3. Egan CE, Stefanova D, Ahmed A, Raja VJ, Thiesmeyer JW, Chen KJ, Greenberg JA, Zhang T, He B, Finnerty BM, Zarnegar R, Jin MM, Scognamiglio T, Dephoure N, Fahey T 3rd, Min IM. CSPG4 Is a Potential Therapeutic Target in Anaplastic Thyroid Cancer. Thyroid. 2021 Jul 5;. doi: 10.1089/thy.2021.0067. [Epub ahead of print] PubMed PMID: 34078123.cspg4-2021.pdf
  4. Gray KD, McCloskey JE, Vedvyas Y, Kalloo OR, Eshaky SE, Yang Y, Shevlin E, Zaman M, Ullmann TM, Liang H, Stefanova D, Christos PJ, Scognamiglio T, Tassler AB, Zarnegar R, Fahey TJ 3rd, Jin MM, Min IM. PD1 Blockade Enhances ICAM1-Directed CAR T Therapeutic Efficacy in Advanced Thyroid Cancer. Clin Cancer Res. 2020 Nov 15;26(22):6003-6016. doi: 10.1158/1078-0432.CCR-20-1523. Epub 2020 Sep 4. PubMed PMID: 32887724; PubMed Central PMCID: PMC7709864.pd1-2020.pdf
  5. Jung M, Yang Y, McCloskey JE, Zaman M, Vedvyas Y, Zhang X, Stefanova D, Gray KD, Min IM, Zarnegar R, Choi YY, Cheong JH, Noh SH, Rha SY, Chung HC, Jin MM. Chimeric Antigen Receptor T Cell Therapy Targeting ICAM-1 in Gastric Cancer. Mol Ther Oncolytics. 2020 Sep 25;18:587-601. doi: 10.1016/j.omto.2020.08.009. eCollection 2020 Sep 25. PubMed PMID: 32995483chimeric2020.pdf
  6. Deh K, Zaman M, Vedvyas Y, Liu Z, Gillen KM, O' Malley P, Bedretdinova D, Nguyen T, Lee R, Spincemaille P, Kim J, Wang Y, Jin MM. Validation of MRI quantitative susceptibility mapping of superparamagnetic iron oxide nanoparticles for hyperthermia applications in live subjects. Sci Rep. 2020 Jan 24;10(1):1171. doi: 10.1038/s41598-020-58219-9. PubMed PMID: 31980695validation2020.pdf
  7. Vedvyas Y, McCloskey JE, Yang Y, Min IM, Fahey TJ, Zarnegar R, Hsu YS, Hsu JM, Van Besien K, Gaudet I, Law P, Kim NJ, Hofe EV, Jin MM. Manufacturing and preclinical validation of CAR T cells targeting ICAM-1 for advanced thyroid cancer therapy. Sci Rep. 2019 Jul 23;9(1):10634. doi: 10.1038/s41598-019-46938-7. PubMed PMID: 31337787manufacturing2019.pdf
  8. Guo H, Kommidi H, Vedvyas Y, McCloskey JE, Zhang W, Chen N, Nurili F, Wu AP, Sayman HB, Akin O, Rodriguez EA, Aras O, Jin MM, Ting R. A Fluorescent, [18F]-Positron-Emitting Agent for Imaging Prostate-Specific Membrane Antigen Allows Genetic Reporting in Adoptively Transferred, Genetically Modified Cells. ACS Chem Biol. 2019 Jul 19;14(7):1449-1459. doi: 10.1021/acschembio.9b00160. Epub 2019 Jun 17. PubMed PMID: 31120734
  9. Amor-Coarasa A, Kelly JM, Singh PK, Ponnala S, Nikolopoulou A, Williams C Jr, Vedvyas Y, Jin MM, Warren JD, Babich JW. [18F]Fluoroethyltriazolyl Monocyclam Derivatives as Imaging Probes for the Chemokine Receptor CXCR4. Molecules. 2019 Apr 24;24(8). doi: 10.3390/molecules24081612. PubMed PMID: 31022852fluoroethyltriazolyl2019.pdf
  10. Kommidi H, Guo H, Nurili F, Vedvyas Y, Jin MM, McClure TD, Ehdaie B, Sayman HB, Akin O, Aras O, Ting R. 18F-Positron Emitting/Trimethine Cyanine-Fluorescent Contrast for Image-Guided Prostate Cancer Management. J Med Chem. 2018 May 10;61(9):4256-4262. doi: 10.1021/acs.jmedchem.8b00240. Epub 2018 Apr 20. PubMed PMID: 2967690918f-positron2018.pdf
  11. Amor-Coarasa A, Kelly J, Ponnala S, Vedvyas Y, Nikolopoulou A, Williams C Jr, Jin MM, David Warren J, Babich JW. [18F]RPS-544: A PET tracer for imaging the chemokine receptor CXCR4. Nucl Med Biol. 2018 May;60:37-44. doi: 10.1016/j.nucmedbio.2018.01.004. Epub 2018 Jan 31. PubMed PMID: 29544122.
  12. Min IM, Shevlin E, Vedvyas Y, Zaman M, Wyrwas B, Scognamiglio T, Moore MD, Wang W, Park S, Park S, Panjwani S, Gray KD, Tassler AB, Zarnegar R, Fahey TJ 3rd, Jin MM. CAR T Therapy Targeting ICAM-1 Eliminates Advanced Human Thyroid Tumors. Clin Cancer Res. 2017 Dec 15;23(24):7569-7583. doi: 10.1158/1078-0432.CCR-17-2008. Epub 2017 Oct 12. PubMed PMID: 29025766cart2017.pdf
  13. Park S, Shevlin E, Vedvyas Y, Zaman M, Park S, Hsu YS, Min IM, Jin MM. Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity. Sci Rep. 2017 Oct 30;7(1):14366. doi: 10.1038/s41598-017-14749-3. PubMed PMID: 29085043micromolar2017.pdf
  14. Vedvyas Y, Shevlin E, Zaman M, Min IM, Amor-Coarasa A, Park S, Park S, Kwon KW, Smith T, Luo Y, Kim D, Kim Y, Law B, Ting R, Babich J, Jin MM. Longitudinal PET imaging demonstrates biphasic CAR T cell responses in survivors. JCI Insight. 2016 Nov 17;1(19):e90064. doi: 10.1172/jci.insight.90064. PubMed PMID: 27882353longitudinal2016.pdf
  15. Eskreis-Winkler S, Deh K, Gupta A, Liu T, Wisnieff C, Jin M, Gauthier SA, Wang Y, Spincemaille P. Multiple sclerosis lesion geometry in quantitative susceptibility mapping (QSM) and phase imaging. J Magn Reson Imaging. 2015 Jul;42(1):224-9. doi: 10.1002/jmri.24745. Epub 2014 Aug 30. PubMed PMID: 25174493multiple2014.pdf
  16. Leelawattanachai J, Kwon KW, Michael P, Ting R, Kim JY, Jin MM. Side-by-Side Comparison of Commonly Used Biomolecules That Differ in Size and Affinity on Tumor Uptake and Internalization. PLoS One. 2015;10(4):e0124440. doi: 10.1371/journal.pone.0124440. eCollection 2015. PubMed PMID: 25901755side2015.pdf
  17. Ren S, Jiang Y, Yoon H, Hong S, Shin D, Lee S, Lee D, Jin MM, Min IM, Kim S. Label-free Detection of the Transcription Initiation Factor Assembly and Specific Inhibition by Aptamers. Bulletin of the Korean Chemical Society. 2014 May; 35(5):1279.label2014.pdf
  18. Meng HW, Pagano JM, White BS, Toyoda Y, Min IM, Craighead HG, Shalloway D, Lis JT, Xiao K, Jin MM. Discovering aptamers by cell-SELEX against human soluble growth factors ectopically expressed on yeast cell surface. PLoS One. 2014;9(3):e93052. doi: 10.1371/journal.pone.0093052. eCollection 2014. PubMed PMID: 24675636discovering2014.pdf
  19. Bae H, Ren S, Kang J, Kim M, Jiang Y, Jin MM, Min IM, Kim S. Sol-gel SELEX circumventing chemical conjugation of low molecular weight metabolites discovers aptamers selective to xanthine. Nucleic Acid Ther. 2013 Dec;23(6):443-9. doi: 10.1089/nat.2013.0437. Epub 2013 Nov 20. PubMed PMID: 24256293.sol2013.pdf
  20. Davis AA, Farrar MJ, Nishimura N, Jin MM, Schaffer CB. Optoporation and genetic manipulation of cells using femtosecond laser pulses. Biophys J. 2013 Aug 20;105(4):862-71. doi: 10.1016/j.bpj.2013.07.012. PubMed PMID: 23972838; PubMed Central PMCIDoptoporation2013.pdf
  21. Kleiman DA, Buitrago D, Crowley MJ, Beninato T, Veach AJ, Zanzonico PB, Jin M, Fahey TJ 3rd, Zarnegar R. Thyroid stimulating hormone increases iodine uptake by thyroid cancer cells during BRAF silencing. J Surg Res. 2013 Jun 1;182(1):85-93. doi: 10.1016/j.jss.2012.08.053. Epub 2012 Sep 8. PubMed PMID: 22998776thyroid2013.pdf
  22. Bu P, Chen KY, Chen JH, Wang L, Walters J, Shin YJ, Goerger JP, Sun J, Witherspoon M, Rakhilin N, Li J, Yang H, Milsom J, Lee S, Zipfel W, Jin MM, Gümüş ZH, Lipkin SM, Shen X. A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells. Cell Stem Cell. 2013 May 2;12(5):602-15. doi: 10.1016/j.stem.2013.03.002. PubMed PMID: 23642368micro2013.pdf
  23. Kim S, Min IM, Ren S, Spector A, Jin MM, Lis JT. Development of temperature-sensitive mutants of the Drosophila melanogaster P-TEFb (Cyclin T/CDK9) heterodimer using yeast two-hybrid screening. Biochem Biophys Res Commun. 2013 Apr 5;433(2):243-8. doi: 10.1016/j.bbrc.2013.02.091. Epub 2013 Mar 7. PubMed PMID: 23500466development2013.pdf
  24. Park S, Kang S, Chen X, Kim EJ, Kim J, Kim N, Kim J, Jin MM. Tumor suppression via paclitaxel-loaded drug carriers that target inflammation marker upregulated in tumor vasculature and macrophages. Biomaterials. 2013 Jan;34(2):598-605. doi: 10.1016/j.biomaterials.2012.10.004. Epub 2012 Oct 23. PubMed PMID: 23099063.tumor2013.pdf

2007 - 2012 (Cornell University)

  1. Wainaina J, Kim NH, Kim J, Jin M, Park SH. Synthesis of magnetite/amphiphilic polymer composite nanoparticles as potential theragnostic agents. Journal of nanoscience and nanotechnology 2012;12:5920-4.j_nanosci_nanotechnol_2012_wainaina.pdf
  2. Li J, Chang S, Liu T, Wang Q, Cui D, Chen X, Jin M, Wang B, Pei M, Wisnieff C, Spincemaille P, Zhang M, Wang Y. Reducing the object orientation dependence of susceptibility effects in gradient echo MRI through quantitative susceptibility mapping. Magn Reson Med 2012;68:1563-9.magn_reson_med_2012_li.pdf
  3. Kang S, Kim CU, Gu X, Owens RM, van Rijn SJ, Boonyaleepun V, Mao Y, Springer TA, Jin MM. Complex Structure of Engineered Modular Domains Defining Molecular Interaction between ICAM-1 and Integrin LFA-1. PLoS One 2012;7:e44124.plos_one_2012_kang.pdf
  4. Hu X, Saha P, Chen X, Kim D, Devarasetty M, Varadarajan R, Jin MM. Cell Surface Assembly of HIV gp41 Six-Helix Bundles for Facile, Quantitative Measurements of Hetero-oligomeric Interactions. J Am Chem Soc 2012;134:14642-5.j._am._chem._soc._2012_hu.pdf
  5. Gu X, Vedvyas Y, Chen X, Kaushik T, Hwang CI, Hu X, Nikitin AY, Jin MM. Novel strategy for selection of monoclonal antibodies against highly conserved antigens: phage library panning against ephrin-b2 displayed on yeast. PLoS One 2012;7:e30680.gu-plosone-2012.pdf
  6. Buitrago D, Keutgen XM, Crowley M, Filicori F, Aldailami H, Hoda R, Liu Y-F, Hoda RS, Scognamiglio T, Jin M, Fahey TJ, Zarnegar R. Intercellular adhesion molecule-1 (ICAM-1) is upregulated in aggressive papillary thyroid carcinoma. Annals of Surgical Oncology 2012;19:973-80.ann._surg._oncol._2012_buitrago.pdf
  7. Wong RL, Liu B, Zhu X, You L, Kong L, Han K-P, Lee H-I, Chavaillaz P-A, Jin M, Wang Y, Rhode PR, Wong HC. Interleukin-15:Interleukin-15 receptor α scaffold for creation of multivalent targeted immune molecules. Protein Eng Des Sel 2011;24:373-83.wong-peds-2011.pdf
  8. Wong R, Chen X, Wang Y, Hu X, Jin MM. Visualizing and Quantifying Acute Inflammation Using ICAM-1 Specific Nanoparticles and MRI Quantitative Susceptibility Mapping. Ann Biomed Eng 2011.wong_2011_abme.pdf
  9. Kang S, Park T, Chen X, Dickens G, Lee B, Lu K, Rakhilin N, Daniel S, Jin MM. Tunable physiologic interactions of adhesion molecules for inflamed cell-selective drug delivery. Biomaterials 2011;32:3487-98.kang-biomaterials-2011.pdf
  10. Chen X, Wong R, Khalidov I, Wang AY, Leelawattanachai J, Wang Y, Jin MM. Inflamed leukocyte-mimetic nanoparticles for molecular imaging of inflammation. Biomaterials 2011;32:7651-61.inflammed2011.pdf
  11. Tremblay JM, Kuo C-L, Abeijon C, Sepulveda J, Oyler G, Hu X, Jin MM, Shoemaker CB. Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases. Toxicon : official journal of the International Society on Toxinology 2010;56:990-8.shoemaker-toxicon-2010.pdf
  12. Park S, Kang S, Veach AJ, Vedvyas Y, Zarnegar R, Kim J-Y, Jin MM. Self-assembled nanoplatform for targeted delivery of chemotherapy agents via affinity-regulated molecular interactions. Biomaterials 2010;31:7766-75.biomaterials-jin-2010.pdf
  13. Owens RM, Gu X, Shin M, Springer TA, Jin MM. Engineering of single Ig superfamily domain of intercellular adhesion molecule 1 (ICAM-1) for native fold and function. J Biol Chem 2010;285:15906-15.jin-jbc-2010.pdf
  14. Lee EZ, Jun Y-S, Hong WH, Thomas A, Jin MM. Cubic mesoporous graphitic carbon(IV) nitride: an all-in-one chemosensor for selective optical sensing of metal ions. Angew Chem Int Ed Engl 2010;49:9706-10.jin-angewchem-2010.pdf
  15. Hu X, Kang S, Lefort C, Kim M, Jin MM. Combinatorial libraries against libraries for selecting neoepitope activation-specific antibodies. Proc Natl Acad Sci U S A 2010;107:6252-7.jin-pnas-2010.pdf
  16. Parks AR, Li Z, Shi Q, Owens RM, Jin MM, Peters JE. Transposition into replicating DNA occurs through interaction with the processivity factor. Cell 2009;138:685-95.parks-2009-cell.pdf
  17. Owens RM, Wang C, You JA, Jiambutr J, Xu ASL, Marala RB, Jin MM. Real-time quantitation of viral replication and inhibitor potency using a label-free optical biosensor. J Recept Signal Transduct Res 2009;29:195-201.owens-jrst-2009.pdf
  18. Mao Y, Balkin DM, Zoncu R, Erdmann KS, Tomasini L, Hu F, Jin MM, Hodsdon ME, De Camilli P. A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism. EMBO J 2009;28:1831-42.mao-embo-2009.pdf
  19. Hu X, Kang S, Chen X, Shoemaker CB, Jin MM. Yeast surface two-hybrid for quantitative in vivo detection of protein-protein interactions via the secretory pathway. J Biol Chem 2009;284:16369-76.hu-jbc-2009.pdf
  20. Zhang H, Casasnovas JM, Jin M, Liu J-h, Gahmberg CG, Springer TA, Wang J-h. An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5. Mol Cell 2008;31:432-7.zhang-molcell-2008.pdf
  21. Fitzgerald JB, Jin M, Chai DH, Siparsky P, Fanning P, Grodzinsky AJ. Shear- and compression-induced chondrocyte transcription requires MAPK activation in cartilage explants. J Biol Chem 2008;283:6735-43.fitzgerald-2008-jbc.pdf
  22. Lee S, Kim YS, Jo M, Jin M, Lee D-k, Kim S. Chip-based detection of hepatitis C virus using RNA aptamers that specifically bind to HCV core antigen. Biochem Biophys Res Commun 2007;358:47-52.chip2007.pdf
  23. Lee H-W, Kim T-I, Chan KH, Kwon M-H, Kim J-S, Jin M, Kim Y-S. Inducing rigid local structure around the zinc-binding region by hydrophobic interactions enhances the homotrimerization and apoptotic activity of zinc-free TRAIL. Biochem Biophys Res Commun 2007;362:766-72.inducing2007.pdf

2000 - 2006 (MIT, Harvard Medical School)

  1. Jin M, Song G, Carman CV, Kim Y-S, Astrof NS, Shimaoka M, Wittrup DK, Springer TA. Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity. Proc Natl Acad Sci U S A 2006;103:5758-63.
  2. Fitzgerald JB, Jin M, Grodzinsky AJ. Shear and compression differentially regulate clusters of functionally related temporal transcription patterns in cartilage tissue. J Biol Chem 2006;281:24095-103.
  3. Kurz B, Domm C, Jin M, Sellckau R, Schünke M. Tissue Engineering of Articular Cartilage under the Influence of Collagen I/III Membranes and Low Oxygen Tension. Tissue engineering 2004;10:1277-86.
  4. Kisiday JD, Jin M, DiMicco MA, Kurz B, Grodzinsky AJ. Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds. J Biomech 2004;37:595-604.
  5. Jin M, Andricioaei I, Springer TA. Conversion between three conformational states of integrin I domains with a C-terminal pull spring studied with molecular dynamics. Structure 2004;12:2137-47.
  6. Fitzgerald JB, Jin M, Dean D, Wood DJ, Zheng MH, Grodzinsky AJ. Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP. J Biol Chem 2004;279:19502-11.
  7. Klerman EB, Adler GK, Jin M, Maliszewski AM, Brown EN. A statistical model of diurnal variation in human growth hormone. Am J Physiol Endocrinol Metab 2003;285:E1118-26.
  8. Jin M, Emkey GR, Siparsky P, Trippel SB, Grodzinsky AJ. Combined effects of dynamic tissue shear deformation and insulin-like growth factor I on chondrocyte biosynthesis in cartilage explants. Arch Biochem Biophys 2003;414:223-31.
  9. Kisiday J, Jin M, Kurz B, Hung H, Semino C, Zhang S, Grodzinsky AJ. Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc Natl Acad Sci U S A 2002;99:9996-10001.
  10. Jin M, Grodzinsky AJ, Wuerz TH, Emkey GR, Wong M, Hunziker EB. Influence of Tissue Shear Deformation on Matrix Electromechanics and Metabolism in Cartilage Explants. In: Kuettner KE, editor. The Many Faces of Osteoarthritis ed by Kuettner: Birkhäuser Verlag AG; 2002.
  11. Kurz B, Jin M, Patwari P, Cheng DM, Lark MW, Grodzinsky AJ. Biosynthetic response and mechanical properties of articular cartilage after injurious compression. J Orthop Res 2001;19:1140-6.
  12. Jin MS, Grodzinsky AJ. Effect of electrostatic interactions between glycosaminoglycans on the shear stiffness of cartilage: A molecular model and experiments. Macromolecules 2001;34:8330-9.
  13. Jin M, Frank EH, Quinn TM, Hunziker EB, Grodzinsky AJ. Tissue shear deformation stimulates proteoglycan and protein biosynthesis in bovine cartilage explants. Arch Biochem Biophys 2001;395:41-8.
  14. Grodzinsky AJ, Levenston ME, Jin M, Frank EH. Cartilage tissue remodeling in response to mechanical forces. Annu Rev Biomed Eng 2000;2:691-713.
  15. Frank EH, Jin M, Loening AM, Levenston ME, Grodzinsky AJ. A versatile shear and compression apparatus for mechanical stimulation of tissue culture explants. J Biomech 2000;33:1523-7.