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        <description>Current Members
   Moonsoo M. Jin, Ph.D. 
Principal Investigator 
B.S.1997 Mechanical Engineering. SNU 
Sc.D. 2002 Mechanical Engineering. MIT 
Publications   Postdoctoral Researchers      Yanping Yang 
B.S. 2012 &amp; Ph.D. 2017 College of Chemistry, Beijing Normal University 
Next-generation CAR T development</description>
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Developing CAR T cells for cancer therapy
We are developing CAR T cells against new tumor antigens, novel CAR constructs for simultaneous therapy and imaging, and various ways to augment the potency of CAR T therapy against solid cancers. Our recent success include demonstration of somatostatin receptor-2 (SSTR2) for imaging T cell distribution and activity in vivo using PET/CT, and developing micromolar affinity CAR T cells to be selective to antigens over-expressed in tumor/tumor str…</description>
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Our interest is in developing molecules and cells for imaging and therapy applications. Essential to this effort is the use of molecular and cellular engineering, built on complementary use rational design and directed evolution approaches. Specific examples include designing new formats of antibodies for molecular imaging and bispecific recognition, and modification of T cells for expression of chimeric antigen or novel T-cell receptors (CAR or TCR). We utilize diverse molecular biol…</description>
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