About us

Our interest is in developing molecules and cells for imaging and therapy applications. Essential to this effort is the use of molecular and cellular engineering, built on complementary use rational design and directed evolution approaches. Specific examples include designing new formats of antibodies for molecular imaging and bispecific recognition, and modification of T cells for expression of chimeric antigen or novel T-cell receptors (CAR or TCR). We utilize diverse molecular biology, biochemistry, and biophysical methods, and imaging tools such as whole body optical imaging, MRI, CT, and PET. Our CAR T cells developed to treat aggressive, refractory thyroid cancer are being evaluated for safety and efficacy in a phase I study (NCT04420754).

Our laboratory is part of Molecular Imaging Innovations Institute (MI3), Department of Radiology, Weill Cornell Medicine, and is located at Belfer Research Building, 413 E 69th St., New York, NY 10065.