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| labmembers:polymer_nanoparticles_for_targeted_delivery_of_therapeutics_and_magnetic_resonance_imaging_contrast_agents 2010/04/25 13:53 | labmembers:polymer_nanoparticles_for_targeted_delivery_of_therapeutics_and_magnetic_resonance_imaging_contrast_agents 2010/04/25 18:37 current | ||
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| Previous work with amphiphilic urethane acrylate nonionomer (UAN) polymer nanoparticles yielded positive results; these particles proved to be fully functionalizable, and targeted delivery of therapeutics was a success. While UAN is entirely capable of encapsulating and delivering constrast agents (such as super paramagnetic iron oxide [SPIO]), this encapsulation compromises the ability to deliver a therapeutic payload as well. | Previous work with amphiphilic urethane acrylate nonionomer (UAN) polymer nanoparticles yielded positive results; these particles proved to be fully functionalizable, and targeted delivery of therapeutics was a success. While UAN is entirely capable of encapsulating and delivering constrast agents (such as super paramagnetic iron oxide [SPIO]), this encapsulation compromises the ability to deliver a therapeutic payload as well. | ||
| - | We have attempted to overcome this issue by crosslinking UAN chains with urethane acrylate anionomer (UAA) chains, capable of conjugating and delivering SPIO via reactive carboxylate species. This leaves the internal cavity free to carry a therapeutic payload, allowing the particle to act both as a target-specific contrast agent and a drug delivery vehicle. | + | We have attempted to overcome this issue by crosslinking UAN chains with urethane acrylate anionomer (UAA) chains, capable of conjugating and delivering SPIO via reactive carboxylate species. This leaves the internal cavity free to carry a therapeutic payload, allowing the particle to act both as a target-specific contrast agent and drug delivery vehicle. |
| {{:labmembers:uan_uaa.jpg?409.6|UAN-UAA Nanoparticle(s)}} | {{:labmembers:uan_uaa.jpg?409.6|UAN-UAA Nanoparticle(s)}} | ||