Stabilized Immunoliposomes for Targeted Drug Delivery
Nwanyinma Nnodum (M.Eng 2009), Christopher Liu (M.Eng 2010)

This project looks to address the problem of specific targeting of nanoparticles. In this case, unilamillar liposomes are prepared and surface modified with proteins for specific targeting such as integrin mAb. These nanoparticles are to then entrap siRNA, magnetic nanoparticles, and/or crystallized drugs to result in target stabilized nanoparticles (tsNPs) for delivery of therapeutics. These tsNPs will undergo in vitro testing to determine their effectiveness. Applications for this project include tumor targeting, analysis of virus uptake and membrane interactions.
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Figure 1. Liposomes are most widely used and developed for drug delivery. Drugs and fluorophores are encapsulated and the surface is modified for targeting and for prolonging residence time in body.

Contact: cjl235@cornell.edu