About the Jin Lab

Our research interests lie broadly in cancer immunotherapy and nanotechnology for early, sensitive detection of cancer and inflammation, and toward improved therapy through site-specific delivery of therapeutics. For these goals, we develop biomolecules (antibodies, nucleic acids, and other proteins), nano-sized particles, and engineered immune cells (T and NK cells), and validate these components in animal model of human diseases for their ability to detect and treat disease. We employ a variety of imaging techniques (whole body optical imaging, MRI, PET) to evaluate real-time distribution and targeted localization of particles and cells.

Current research topics include:

  • Global, unbiased mining of human antibodies maintaining native pairing of Ig heavy and light chains
  • Engineering diagnostic and therapeutic nanoparticles toward cancer to allow image-guided drug delivery
  • Engineering of T/NK cells to recognize tumors through chimeric antigen receptor and magnetism-guided localization

Quantitative Mapping of Inflammation by QSM (for details refer to Research) A brief overview of the Quantitative Susceptibility Mapping (QSM) process. A mouse is scanned using a typical multi-echo gradient echo 3D MRI sequence and modeled for 3D analysis. QSM reconstructions allow for localized observation and quantification of super-paramagnetic iron oxide (SPIO) nanoparticles in specific areas of the subject.

T cell imaging sstr2-icam.jpg

 
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